Griffith was born on August 9, 1957, in New York City, to actress Tippi Hedren and producer, former actor, and advertising executive Peter Griffith. Her mother's ancestry is Swedish, German, and Norwegian.

Griffith's parents divorced when she was four years old, after which her father married model/actress Nanita Greene and had two more children: actress Tracy Griffith and set designer Clay A. Griffith. Her mother married agent and producer Noel Marshall, and Griffith grew up with three stepbrothers.

Melanie Griffith's Family Tree