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GeneaNet : Community : Genealogy Blog Monday Mar 15, 2010

Genealogy Blog 


11 March 2010

Actress Glenn Close Has Genome Mapped

Glenn Close has played a manipulative aristocrat, a Dalmatian-skinning mastermind and is now best known as a high-stakes litigator. She writes a blog about celebrity dogs, is on her third marriage and roots for the New York Mets.

That's probably more than you'd care to know about Glenn Close, but scientists now know a whole lot more than that: The actress has become the first identified woman to have her entire genomic sequence decoded.

Close's genome shared a 95 percent similarity with genomes that have already been fully mapped. It also offered up 379,000 new DNA variations, called SNPs, for researchers to analyze.

Source & Full Story

7 March 2010

Major East-West Division Underlies Y Chromosome Stratification Across Indonesia

The early history of Island Southeast Asia is often characterized as the story of two major population dispersals: the initial Paleolithic colonization of Sahul ~45 thousand years ago and the much later Neolithic expansion of Austronesian-speaking farmers ~4,000 years ago. Here, in the largest survey of Indonesian Y chromosomes to date, we present evidence for multiple genetic strata that likely arose through a series of distinct migratory processes. We genotype an extensive battery of Y chromosome markers, including 85 SNPs/indels and 12 Y-STRs, in a sample of 1,917 men from 32 communities located across Indonesia.

We find that the paternal gene pool is sharply subdivided between western and eastern locations, with a boundary running between the islands of Bali and Flores. Analysis of molecular variance reveals one of the highest levels of between-group variance yet reported for human Y chromosome data.

Source & Full Story

6 March 2010

Lost Jewish Tribe 'Found In Zimbabwe'

The Lemba people are easy to distinguish from most other Zimbabweans - they wear skull caps, pray in a language which is a mixture of Hebrew and Arabic, and put the Star of David on their gravestones.

Their oral traditions claim that their ancestors were Jews who fled the Holy Land about 2,500 years ago.

It may sound like another myth of a lost tribe of Israel, but British scientists have carried out DNA tests which confirm their Semitic origin.

These tests back up the group's belief that a group of perhaps seven men married African women and settled on the continent.

Source & Full Story

4 March 2010

Ancestral Puebloan mtDNA In Context Of The US Greater Southwest

Ancient DNA (aDNA) was extracted from the human remains of seventy-three individuals from the Tommy and Mine Canyon sites (dated to PI-II and PIII, respectively), located on the B-Square Ranch in the Middle San Juan region of New Mexico. The mitochondrial DNA (mtDNA) haplogroups of 48 (65.7%) of these samples were identified, and their frequency distributions were compared with those of other prehistoric and modern populations from the Greater Southwest and Mexico.

The haplogroup frequency distributions for the two sites were statistically significantly different from each other, with the Mine Canyon site exhibiting an unusually high frequency of haplogroup A for a Southwestern population, indicating the possible influence of migration or other evolutionary forces. However, both sites exhibited a relatively high frequency of haplogroup B, typical of Southwestern populations, suggesting continuity in the Southwest, as has been hypothesized by others. The first hypervariable region of twenty-three individuals (31.5%) was also sequenced to confirm haplogroup assignments and compared with other sequences from the region. This comparison further strengthens the argument for population continuity in the Southwest without a detectable influence from Mesoamerica.

Source & Full Story

28 February 2010

The mtDNA Composition Of Uzbekistan: A Microcosm Of Central Asian Patterns

In order to better characterize and understand the mtDNA population genetics of Central Asia, the mtDNA control regions of over 1,500 individuals from Uzbekistan have been sequenced. Although all samples were obtained from individuals residing in Uzbekistan, individuals with direct ancestry from neighboring Central Asian countries are included.

Individuals of Uzbek ancestry represent five distinct geographic regions of Uzbekistan: Fergana, Karakalpakstan, Khorezm, Qashkadarya, and Tashkent. Individuals with direct ancestry in nearby countries originate from Kazakhstan, Kyrgyzstan, Russia, Afghanistan, Turkmenistan, and Tajikistan. Our data reinforce the evidence of distinct clinal patterns that have been described among Central Asian populations with classical, mtDNA, and Y-chromosomal markers.

Source & Full Story

25 February 2010

DNA Tests Used to Identify Dead Soldier from Korean War

DNA testing has identified the remains of a South Korean soldier believed to be killed during the Korean War, only the third such case using DNA results in South Korea, the defense ministry said Thursday.

The remains have been identified as belonging to the late Pfc. Yang Son-ho, who was 27 years old at the time, after forensic experts at the defense ministry confirmed his DNA information matching those of his 60-year-old daughter, according to the ministry.

Yang's remains were discovered in 2007 in Gapyeong, roughly 60 km from Seoul, after the government began a project in 2000 to locate and unearth missing military personnel from the Korean War that lasted from 1950 to 1953.

Source & Full Story

18 February 2010

Archbishop Tutu is part Bushman, DNA study reveals

Scientists said Wednesday they had sequenced the genome of Bushmen, the longest-surviving lineage of modern humans, expanding our understanding of genetic diversity and inherited disease.

Comparison of DNA provided by a Bushman elder and South African Archbishop Desmond Tutu showed that Tutu is partly of Bushman heritage, they added.

The 78-year-old Nobel winner voiced "astonishment and delight" at the news, a researcher told AFP.

Bushmen is the collective term for linguistically-distinct groups of hunter-gatherers who inhabit the Kalahari Desert, which straddles parts of Botswana, Namibia and South Africa.

Source & Full Story

17 February 2010

Study Examines Family Lineage of King Tutankhamun

From September 2007 to October 2009, royal mummies underwent detailed anthropological, radiological, and genetic studies (DNA was extracted from 2 to 4 different biopsies per mummy). In addition to Tutankhamun, 10 mummies (circa 1410-1324 B.C.) possibly or definitely closely related in some way to Tutankhamun were chosen; of these, the identities were certain for only 3. In addition to these 11 mummies, 5 other royal individuals dating to the early New Kingdom (circa 1550-1479 B.C.) were selected that were distinct from the supposed members of the Tutankhamun lineage.

The researchers found that several of the anonymous mummies or those with suspected identities were now able to be addressed by name, which included KV35EL, who is Tiye, mother of the pharaoh Akhenaten and grandmother of Tutankhamun, and the KV55 mummy, who is most probably Akhenaten, father of Tutankhamun. This kinship is supported in that several unique anthropological features are shared by the 2 mummies and that the blood group of both individuals is identical. The researchers identified the KV35YL mummy as likely Tutankhamun's mother.

Source & Full Story

16 February 2010

Putative Skull of Saint Bridget of Sweden Probably Not Authentic

The putative skull of Saint Bridget (Birgitta) of Sweden that has been kept in a shrine in Vadstena Abbey is probably not authentic. A new study conducted at Uppsala University reveals that the two skulls, believed to be from Saint Bridget and her daughter Catherine (Katarina), are not from maternally related individuals. Furthermore, dating shows that the skulls are not from the time period when Bridget and Catherine lived.

Vadstena parish assigned Associate Professor Marie Allen's research group at Uppsala University's Department of Genetics and Pathology the task of examining DNA from both skulls, in order to confirm kinship and authenticity. A sensitive method based on analysis of the maternally inherited mitochondrial DNA was used to analyse the skulls. This method makes it possible to examine very small amounts of DNA, and it is often a successful analysis on aged and degraded material.

Saint Bridget of Sweden lived between 1303 and 1373, and was canonized in 1391.

Source & Full Story

Should We Clone Neanderthals?

If Neanderthals ever walk the earth again, the primordial ooze from which they will rise is an emulsion of oil, water, and DNA capture beads engineered in the laboratory of 454 Life Sciences in Branford, Connecticut. Over the past 4 years those beads have been gathering tiny fragments of DNA from samples of dissolved organic materials, including pieces of Neanderthal bone. Genetic sequences have given paleoanthropologists a new line of evidence for testing ideas about the biology of our closest extinct relative.

The first studies of Neanderthal DNA focused on the genetic sequences of mitochondria, the microscopic organelles that convert food to energy within cells. In 2005, however, 454 began a collaborative project with the Max Planck Institute in Leipzig, Germany, to sequence the full genetic code of a Neanderthal woman who died in Croatia's Vindija cave 30,000 years ago. As the Neanderthal genome is painstakingly sequenced, the archaeologists and biologists who study it will be faced with an opportunity that seemed like science fiction just 10 years ago. They will be able to look at the genetic blueprint of humankind's nearest relative and understand its biology as intimately as our own.

Source & Full Story

Family Tree DNA Announces Family Finder

Family Tree DNA announces Family Finder: "With our autosomal Family Finder test you may extend the power of genetic genealogy to all of your ancestors. Using a test of your own DNA, you can discover connections to descendants of all sixteen of your great-great-grandparents! The Family Finder test will not only open avenues for traditional research but will help you discover the hidden connections that could explain your family’s migrations.

We place you in control. When you take the Family Finder test, your results are compared against our Family Finder database. Your list of matches is designed to be quickly sorted to allow you to focus on your near or distant cousins. Because email addresses are provided for easy communication with your near or distant cousins you will be able to share research easily. We notify you by email when you have new matches. Your raw data file is freely available for download."

FTDNA Family Finder

10 February 2010

Ancient DNA Points To Additional New World Migration

A 4,000-year-old Greenland man just entered the scientific debate over the origins of prehistoric populations in the Americas.

A nearly complete sequence of nuclear DNA extracted from strands of the long-dead man’s hair — the first such sequence obtained from an ancient person — highlights a previously unknown and relatively recent migration of northeastern Asians into the New World about 5,500 years ago, scientists say.

An analysis of differences, or mutations, at single base pairs on the ancient Greenlander’s nuclear genome indicates that his father’s ancestors came from northeastern Siberia, report geneticist Morten Rasmussen of the Natural History Museum of Denmark in Copenhagen and his colleagues in the Feb. 11 Nature.

Source & Full Story

4 February 2010

Darwin Descended From Cro-Magnon Man: Scientists

The father of evolution Charles Darwin was a direct descendant of the Cro-Magnon people, whose entry into Europe 30,000 years ago heralded the demise of Neanderthals, scientists revealed in Australia Thursday.

Darwin, who hypothesised that all humans evolved from common ancestors in his seminal 1859 work "On the Origin of Species", came from Haplogroup R1b, one of the most common European male lineages, said genealogist Spencer Wells.

"Men belonging to Haplogroup R1b are direct descendants of the Cro-Magnon people who, beginning 30,000 years ago, dominated the human expansion into Europe and heralded the demise of the Neanderthal species," Wells said.

Source & Full Story

2 February 2010

Could A Man Who Died In The 1600s Unlock Your Health Secrets?

More people are now looking up their family trees, eager to learn more about their ancestors. But, in a surprising twist, scientists are using family trees to track disease-causing genes.

They are going back in history, sometimes hundreds of years, to track the person who first produced the faulty genes. They're then tracking down other lines of the family tree, to find the modern-day descendants of this person and to warn them of the health dangers they face.

This genetic genealogy, as the science is known, is being developed as a new approach to preventing - and treating - conditions with a strong genetic link such as breast cancer, osteoporosis and depression, as well as rare syndromes that cause fatal insomnia and an inability to feel pain.

Source & Full Story

1 February 2010

Ambassador or Slave? East Asian Skeleton Discovered In Vagnari Roman Cemetery

A team of researchers announced a surprising discovery during a scholarly presentation in Toronto last Friday. The research team, based at McMaster University in Hamilton, Canada, has been helping to excavate an ancient Roman cemetery at the site of Vagnari in southern Italy. Led by Professor Tracy Prowse, they’ve been analyzing the skeletons found there by performing DNA and oxygen isotope tests.

The surprise is that the DNA tests show that one of the skeletons, a man, has an East Asian ancestry – on his mother’s side. This appears to be the first time that a skeleton with an East Asian ancestry has been discovered in the Roman Empire.

Source & Full Story

31 January 2010

Egypt Set To Unveil Tutankhamun DNA Results

One of the great remaining mysteries of ancient Egypt, the lineage of the boy-pharaoh Tutankhamun, may soon be solved, the country's antiquities supremo hinted on Sunday.

Zahi Hawass told AFP he has scheduled a news conference for February 17 in the Cairo Museum to unveil the findings from DNA samples taken from the world's most famous pharaoh.

In August 2008, Egypt's antiquities authorities said they had taken DNA samples from Tutankhamun's mummy and from two foetuses found in his tomb to determine whether the still-born children had been fathered by the boy king.

Hawass said then the DNA tests also would determine Tutankhamun's lineage, and whether the foetuses were the offspring of Tutankhamun and Ankhesenpamon, the daughter of Nefertiti who is renowned as one of history's great beauties.

Source & Full Story

27 January 2010

World’s Largest Repository Of Correlated Genetic Genealogical Information Under Creation In Mali

The Utah Arts Council today announced it has selected Faces of Mali, an exhibit of photographs of village life in western Africa, for its 2010 traveling art program. The show, sponsored by Sorenson Molecular Genealogy Foundation (SMGF) and Mali Rising—two Utah-based non-profit organizations—and the Embassy of Mali, opens a window for viewers into a region with a 600-year history as a center for scholarship and trade. The first traveling exhibit is scheduled for Canyon Community Center in Springdale beginning Feb. 4.

“The people of rural Mali have a culture that is rich in tradition and history and it is delightful that people all over Utah will be able to enjoy this photo essay,” said Samake, Malian honorary consul in Utah. “Many Utahns already have a positive connection with Malians by helping us explore and record our ancestry, build schools and better educate our children.” For five years SMGF has been collecting DNA and family history information from Malians in the process of creating the world’s largest repository of correlated genetic genealogical information. Sandy-based Mali Rising Foundation helps Mali villages develop clean water sources, improve sanitation and build schools.

Source & Full Story

19 January 2010

Most Modern European Males Descend From Farmers Who Migrated From The Near East

A new study from the University of Leicester has found that most men in Europe descend from the first farmers who migrated from the Near East 10,000 years ago. The findings are published January 19 in the open-access journal PLoS Biology.

The invention of farming is perhaps the most important cultural change in the history of modern humans. Increased food production led to the development of societies that stayed put, rather than wandering in search of food. The resulting population growth culminated in the seven billion people who now live on the planet. In Europe, farming spread from the 'Fertile Crescent', a region extending from the eastern Mediterranean coast to the Persian Gulf and including the Tigris and Euphrates valleys.

Source & Full Story

17 December 2009

Inferring Continental Ancestry Of Argentineans From Autosomal, Y-Chromosomal And Mitochondrial DNA

We investigated the bio-geographic ancestry of Argentineans, and quantified their genetic admixture, analyzing 246 unrelated male individuals from eight provinces of three Argentinean regions using ancestry-sensitive DNA markers (ASDM) from autosomal, Y and mitochondrial chromosomes. Our results demonstrate that European, Native American and African ancestry components were detectable in the contemporary Argentineans, the amounts depending on the genetic system applied, exhibiting large inter-individual heterogeneity. Argentineans carried a large fraction of European genetic heritage in their Y-chromosomal (94.1%) and autosomal (78.5%) DNA, but their mitochondrial gene pool is mostly of Native American ancestry (53.7%); instead, African heritage was small in all three genetic systems (<4%).

Population substructure in Argentina considering the eight sampled provinces was very small based on autosomal (0.92% of total variation was between provincial groups, p = 0.005) and mtDNA (1.77%, p = 0.005) data (none with NRY data), and all three genetic systems revealed no substructure when clustering the provinces into the three geographic regions to which they belong. The complex genetic ancestry picture detected in Argentineans underscores the need to apply ASDM from all three genetic systems to infer geographic origins and genetic admixture. This applies to all worldwide areas where people with different continental ancestry live geographically close together.

Source & Full Story

16 December 2009

DNA Of Jesus-Era Shrouded Man In Jerusalem Reveals Earliest Case Of Leprosy

The DNA of a 1st century shrouded man found in a tomb on the edge of the Old City of Jerusalem has revealed the earliest proven case of leprosy.

The burial cave, which is known as the Tomb of the Shroud, is located in the lower Hinnom Valley and is part of a 1st century C.E. cemetery known as Akeldama or 'Field of Blood' (Matthew 27:3-8; Acts 1:19) -- next to the area where Judas is said to have committed suicide. The tomb of the shrouded man is located next to the tomb of Annas, the high priest (6-15 C.E.), who was the father in law of Caiaphas, the high priest who was said to have betrayed Jesus to the Romans. It is thus thought that this shrouded man was either a priest or a member of the aristocracy. According to Prof. Gibson, the view from the tomb would have looked directly toward the Jewish Temple.

Details of the research will be published December 16 in the journal PLoS ONE.

Source & Full Story

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